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The United Kingdom recorded 34,526 new cases of coronavirus and 167 more coronavirus-related deaths in the last 24 hours, according to government data.
The numbers compare with 37,960 infections and 40 deaths reported on Monday, while 31,564 infections and 203 deaths were announced this time last week.
There are currently 7,000 COVID patients in hospital.
Meanwhile, another 24,919 people received their first dose of the coronavirus vaccine on Monday, bringing the total number who received a single hit to 48,765,726 (89.7% of those over 16 years old).
Another 33,177 received doses on Monday, which means that 4,479,748 have now been fully vaccinated in the UK (82.4%).
Government data showed that since the start of the pandemic, a total of 136,375 people in the UK have died within 28 days of having tested positive for COVID.
Separate figures published by the Office for National Statistics (ONS) showed that a total of 851 deaths pointing to COVID-19 on the death certificate were recorded in England and Wales in the week ending September 17, a slight decrease of 1% from the previous week.
One in 13 cases (7.7%) of deaths recorded in England and Wales up to that week mentioned coronavirus on the death certificate.
The Office for National Statistics said a total of 161,446 deaths indicating COVID on the death certificate occurred in the UK.
The highest number in a single day occurred on January 19.
During the first wave of the virus, the daily death toll peaked at 1,461 on April 8, 2020.
It comes as Boris Johnson has promised to appoint someone to head the public inquiry into the coronavirus pandemic by Christmas.
The Prime Minister also said he supported the National COVID-19 Memorial Wall and suggested that it could become a permanent national monument to the pandemic.
Meanwhile, ONS research has found that more than one in 10 high school students and more than a third of school staff who have contracted COVID have persistent symptoms.
Both staff and pupils most commonly reported weakness and fatigue, while staff were more likely to have shortness of breath.
The Office for National Statistics estimates that 35.7% of staff and 12.3% of students who previously tested positive for COVID reported persistent symptoms more than a month after contracting the virus.
About 15.5% of staff and 9.4% of pupils said that their ability to perform daily tasks had decreased significantly.
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