Coronavirus in the US: More Covid-19 boosters are coming. But not everyone needs one, experts say

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Moderna’s EUA request reflected the groups authorized to receive a booster dose of Pfizer’s mRNA vaccine. Third doses of the Moderna and Pfizer Covid-19 vaccines have already been approved for some immunocompromised people.

Still, some experts note that while the antibodies may decline over time, the initial two-dose regimen for both vaccines still holds up against severe Covid-19 infection.

dr. Paul Offit, a member of the FDA Vaccines and Related Biological Products Advisory Committee that held the vote, told CNN’s Wolf Blitzer on Thursday that good expectations should be set about what vaccines should do and how they stay effective.

“We need to determine what the purpose of this vaccine is. If the purpose of this vaccine is protection against a serious illness, that is, the kind of illness that causes you to seek medical attention or go to the hospital or ICU, then current vaccines, such as two-dose vaccines, do just that,” he said. “So you don’t really need a booster dose, at least in terms of that data.”

The committee’s advice is the same as that given last month for the third dose of Pfizer/BioNTech: it is approved for people over 65 years of age and people aged 18 and over who are at risk of serious illness or who live or work in a situation where they are at higher risk of complications or serious illness.

Offit said that while he voted to recommend half-dose booster shots for some people six months after their first two doses of Moderna’s vaccine, he doesn’t think everyone needs one.

“I do worry about the kind of 18- to 29-year-olds because that’s the group at higher risk for myocarditis — that’s inflammation of the heart muscle,” he said. “So, with no apparent benefit of needing that third dose, I think we’ve created this kind of ‘third dose fever’ in this country because of the way this has played out.”

dr. Michael Kurilla, director of the division of clinical innovation at the National Center for Advancing Translation Sciences at the National Institutes of Health, agreed.

“I don’t see the need for a booster let-it-rip campaign,” Kurilla said.

US donates more than 17 million Johnson & Johnson Covid-19 vaccines to the African Union
More than 9 million people have received a booster dose of coronavirus vaccine, according to the latest data from the US Centers for Disease Control and Prevention, which is nearly 5% of those who had already been fully vaccinated.

According to CDC data, the number of people receiving booster doses currently exceeds the number of people receiving their first dose of vaccine. More than a million doses were reported on Wednesday, but only about 230,000 people on average start the vaccination process every day.

President Joe Biden highlighted progress from the moment nearly 100 million eligible Americans went unvaccinated in July, but said the nation is in a “very critical period” and urged more needs to be done.

“We are at 66 million, still an unacceptably high number of unvaccinated people,” he said on Thursday. “This is not the time to give up.”

The FDA will consider the committee’s recommendations, and if an EUA is approved, the CDC will discuss eligibility groups.

Johnson & Johnson vaccine boosters will be considered Friday, as well as a presentation on mix-and-match vaccines.

Vaccine mandates are moving forward

As the debate over boosters continues, experts consistently point to the greater need to vaccinate unvaccinated individuals to stay ahead of the pandemic. And while many campaigns to mandate Covid-19 vaccines from the public and private sectors have been successfully received, some agencies are experiencing backlash from a vocal subset.

In Chicago, the police union president said up to half of city officials could be placed on unpaid leave from Friday because individuals failed to report their vaccination status, as required by the city. Police said this week it will be fully staffed to go into the weekend.

Many state employees in Washington are four days away from a deadline to be fully vaccinated against Covid-19, and officials will not extend that deadline any further.

“If people make the choice to leave public service, we will replace them,” Governor Jay Inslee said Thursday.

Up to half of Chicago police officers could get unpaid leave over vaccine dispute

More than 90% of state employees have given proof of vaccination, Inslee said, and about two percent more have received special accommodations that allow them to remain unvaccinated due to medical conditions or religious beliefs.

In Nevada, the intensive care units of rural hospitals stretched to their limits may face a staff shortage as a mandate to vaccinate a health worker goes into effect Nov. 1.

“We know there are staff members who refuse to be vaccinated,” Joan Hall, president of Nevada Rural Hospital Partners, said in a briefing Thursday. Vaccination rates for employees in their hospitals range from 60% to 90%, Hall said.

But experts have consistently pointed out that areas with higher vaccination rates do better with Covid-19 hospitalizations.

New York City has an indoor vaccine mandate for many companies, and Mayor Bill de Blasio said on Thursday that 85% of adult residents have received at least one dose of Covid-19 vaccine.

According to Dr. NYC Health + Hospitals CEO Mitchell Katz, the number of Covid-19 hospitalizations in the city’s public health system has reached its lowest point since the start of the pandemic.

Wider distribution for third doses of Moderna Covid-19 vaccine under consideration

Application of antiviral pills will be reviewed

Vaccines have been proven to be the most effective means of Covid-19 protection, but the measure is preventive. An antiviral pill that can help newly infected people is now scheduled for review next month.

The FDA’s advisory committee on antimicrobial drugs will meet on Nov. 30 to discuss Merck and Ridgeback’s emergency use approval application for its experimental Covid-19 antiviral drug molnupiravir, the agency announced Thursday.

If finally approved, the drug – which comes in capsule form – would be the first oral antiviral treatment to fight Covid-19.

What would an antiviral pill mean in the fight against Covid-19?
Preliminary results showed that 7.3% of the 385 patients who received the antiviral drug were either hospitalized or died from Covid-19, compared with 14.1% of the 377 patients who received a placebo, Merck said earlier this week. month.

“Up to Day 29, no deaths were reported in patients receiving molnupiravir, compared with 8 deaths in patients receiving placebo,” the statement said.

The FDA noted that it doesn’t always call an advisory committee meeting to discuss a potential EUA, but it can when the committee discussion would help inform the agency’s decision-making.

“We believe that in this case, a public discussion of this data with the agency’s advisory committee will help to gain a clear understanding of the scientific data and information that the FDA is evaluating to make a decision about the whether or not to authorize this treatment for emergency use,” Dr. Patrizia Cavazzoni, director of the FDA’s Center for Drug Evaluation and Research, said in a statement.

Virginia Langmaid, Jen Christensen, Maggie Fox, Lauren Mascarenhas, Andy Rose, Peter Nickeas, Laura Ly and Casey Riddle of CNN contributed to this report.

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