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The researchers immunized mice with nanoparticles that mimic SARS-CoV-2 by displaying multiple copies of the receptor-binding domain (RBD) antigen.
The results of their protein-based vaccine have been published in ACS Central Science.
The team made nanoparticles similar in size to SARS-CoV-2 and decorated them with many RBDs. They injected them into mice, along with separate nanoparticles containing an adjuvant, in two doses three weeks apart.
For comparison, they immunized another group of mice with polymersomes that encapsulated RBD, as well as nanoparticles containing the adjuvant.
Although both groups of mice produced high levels of RBD-specific antibodies, only the surface-decorated nanoparticles generated neutralizing antibodies that prevented SARS-CoV-2 infection in the cells.
Source: American Chemical Society
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