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These results, published in Nature Communication, shows the most sophisticated in vitro model of a mammal created, a major step in mimicking the natural development of a mammal via stem cells.
This new model is not a complete mouse and cannot become one. The anterior part of the brain and other important parts are still missing.
Stem cells replace specialized cells that are damaged or lost. They can divide over and over again to produce new cells and become our heart, brain, bones, and nerves.
Stem cell research offers hope in the treatment of debilitating diseases such as diabetes, Parkinson’s disease and Huntington’s disease.
“The knowledge we have gained throughout our career as a developmental biologist was the starting point for this study in the field of stem cells,” said Christine Thisse. “It was a big leap for us, but it shows that if you have a solid idea, it can be used to break through barriers and can be developed for other purposes. I say this for the students: nothing is final, there is room to learn more and to solve problems.
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“Watching an embryo develop is a wonderful thing to see,” Thisse added. “I am lucky that my work has led me to contribute to the knowledge of the development of invertebrate and vertebrate embryos, and that by using these principles we were able to produce embryo formation in a box. using stem cells as building bricks. “
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