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REVIEW article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 – 2024 |
doi: 10.3389/fnut.2024.1426551
Provisionally accepted
- 1
Department of Food, Nutrition and Environment Sciences, Faculty of Agricultural and Food Sciences, University of Milan, Milan, Lombardy, Italy - 2
Italian Auxological Institute (IRCCS), Milan, Italy
The final, formatted version of the article will be published soon.
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has emerged as a prevalent health concern, encompassing a wide spectrum of liver-related disorders.Insulin resistance, a key pathophysiological feature of MASLD, can be effectively ameliorated through dietary interventions. The Mediterranean diet, rich in whole grains, fruits, vegetables, legumes, and healthy fats, has shown promising results in improving insulin sensitivity. Several components of the Mediterranean diet, such as monounsaturated fats and polyphenols, exert anti-inflammatory and antioxidant effects, thereby reducing hepatic steatosis and inflammation. Furthermore, this dietary pattern has been associated with a higher likelihood of achieving MASLD remission.In addition to dietary modifications, physical exercise, particularly resistance exercise, plays a crucial role in enhancing metabolic flexibility. Resistance exercise training promotes the utilization of fatty acids as an energy source. It enhances muscle glucose uptake and glycogen storage, thus reducing the burden on the liver to uptake excess blood glucose. Furthermore, resistance exercise stimulates muscle protein synthesis, contributing to an improved muscle-to-fat ratio and overall metabolic health.When implemented synergistically, the Mediterranean diet and resistance exercise can elicit complementary effects in combating MASLD. Combined interventions have demonstrated additive benefits, including greater improvements in insulin resistance, increased metabolic flexibility, and enhanced potential for MASLD remission. This underscores the importance of adopting a multifaceted approach encompassing dietary modifications and regular physical exercise to effectively manage MASLD.This narrative review explores the biological mechanisms of diet and physical exercise in addressing MASLD by targeting insulin resistance and decreased metabolic flexibility.
Keywords:
MASLD, physical exercise, Insulin Resistance, metabolic flexibility, mediterranean diet, Resistance exercise
Received:
01 May 2024;
Accepted:
06 Aug 2024.
Copyright:
© 2024 Paola Mambrini, Grillo, Colosimo, Zarpellon, Pozzi, Furlan, Amodeo and Bertoli. This is an
open-access article distributed under the terms of the
Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,
provided the original author(s) or licensor are credited and that the
original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which
does not comply with these terms.
* Correspondence:
Santo Colosimo, Department of Food, Nutrition and Environment Sciences, Faculty of Agricultural and Food Sciences, University of Milan, Milan, 20122, Lombardy, Italy
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